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#TALK Research - Middlemore Clinical Trials Newsletter

Mar 08, 2022

Welcome to the March Edition of #TALK.Research

The requests for Middlemore Clinical Trials to be involved in clinical trials has never been greater. Across all therapeutic areas there are partners wishing to have the hospital involved in clinical trials trialling novel products. Access to such trials can help address some of the health inequity that exists in our community. The number of investigator initiated and collaborative group trials also is increasing with hospital researchers in many departments successful in recent funder rounds.

The Renal department has some excellent researchers and a huge number of patients requiring access to improved therapies. One of the ways this can happen is through clinical trials that the department is involved in and will be throughout the year.

With your support we look forward to a continued busy year here at MMCT.

Maa te waa,

Dr Edward Watson

What's in this issue:

Featured Department - Renal
Recent Publications by CMH Investigators
MMCT is now on Twitter
Meet the Team - Sharon Cheung (Business Associate)
Trials Starting at MMCT and Trial Statistics
Clinical Trial Referral App available to download

Featured Department - Renal

March is Kidney Health month, which is an opportunity to highlight the great work the Renal department does for the Counties Manukau catchment. Counties Manukau Health (CMH) Renal service is the largest Renal department in New Zealand due to the highest prevalence of patients requiring dialysis, at 4% in 2020. Maaori and Pasifika patients make up 80% of our patients. Currently we have 700 dialysis patients, 230 of whom do their dialysis at home. In our dialysis population, diabetic kidney disease is the most common cause of end stage kidney disease (ESKD) accounting for 2/3 of the patients.

The CMH Renal department provides a wide range of both in-patient and out-patient services for acute and chronic presentations, for all fields of Nephrology including: dialysis, renal transplantation, chronic kidney disease, hypertension, supportive care and procedures. We have a particular focus amongst our whole team on home based dialysis and renal transplantation.
The team of physicians are also engaged in both commercial and grant-funded clinical research. This allows the team to bring novel treatments and observational studies to the CMH population.

The Renal department is led by Dr Jamie Kendrick-Jones - Head of Department, with Dr Joanna Dunlop as Deputy Head of Department (2IC). There are three physicians who are currently leading clinical trials as Principal investigators: Dr Hari Talreja, Dr Kalpa Jayanatha and Dr Jamie Kendrick-Jones. All the other Renal physicians have an active interest and expertise in research and support as sub-investigators in these trials and many have lead trials in the past, in particular Dr Mark Marshall, Dr Chris Hood and Dr David Voss.

Click here to read the full article

Recent Publications by CMH Investigators

Gelbart B, McSharry B, Delzoppo C, Erickson S, Lee K, Butt W, Rea M, Wang X, Beca J, Kazemi A, Shann F. Pragmatic Randomized Trial of Corticosteroids and Inhaled Epinephrine for Bronchiolitis in Children in Intensive Care. J Pediatr. 2022 Jan 31:S0022-3476(22)00057-9. doi: 10.1016/j.jpeds.2022.01.031. Epub ahead of print. PMID: 35093318.

Axfors C, Janiaud P, Schmitt AM, Van't Hooft J, Smith ER, Haber NA, Abayomi A, Abduljalil M, Abdulrahman A, Acosta-Ampudia Y, Aguilar-Guisado M, Al-Beidh F, Alejandria MM, Alfonso RN, Ali M, AlQahtani M, AlZamrooni A, Anaya JM, Ang MAC, Aomar IF, Argumanis LE, Averyanov A, Baklaushev VP, Balionis O, Benfield T, Berry S, Birocco N, Bonifacio LB, Bowen AC, Bown A, Cabello-Gutierrez C, Camacho B, Camacho-Ortiz A, Campbell-Lee S, Cao DH, Cardesa A, Carnate JM, Castillo GJJ, Cavallo R, Chowdhury FR, Chowdhury FUH, Ciccone G, Cingolani A, Climacosa FMM, Compernolle V, Cortez CFN, Costa Neto A, D'Antico S, Daly J, Danielle F, Davis JS, De Rosa FG, Denholm JT, Denkinger CM, Desmecht D, Díaz-Coronado JC, Díaz Ponce-Medrano JA, Donneau AF, Dumagay TE, Dunachie S, Dungog CC, Erinoso O, Escasa IMS, Estcourt LJ, Evans A, Evasan ALM, Fareli CJ, Fernandez-Sanchez V, Galassi C, Gallo JE, Garcia PJ, Garcia PL, Garcia JA, Garigliany M, Garza-Gonzalez E, Gauiran DTV, Gaviria García PA, Giron-Gonzalez JA, Gómez-Almaguer D, Gordon AC, Gothot A, Grass Guaqueta JS, Green C, Grimaldi D, Hammond NE, Harvala H, Heralde FM, Herrick J, Higgins AM, Hills TE, Hines J, Holm K, Hoque A, Hoste E, Ignacio JM, Ivanov AV, Janssen M, Jennings JH, Jha V, King RAN, Kjeldsen-Kragh J, Klenerman P, Kotecha A, Krapp F, Labanca L, Laing E, Landin-Olsson M, Laterre PF, Lim LL, Lim J, Ljungquist O, Llaca-Díaz JM, López-Robles C, López-Cárdenas S, Lopez-Plaza I, Lucero JAC, Lundgren M, Macías J, Maganito SC, Malundo AFG, Manrique RD, Manzini PM, Marcos M, Marquez I, Martínez-Marcos FJ, Mata AM, McArthur CJ, McQuilten ZK, McVerry BJ, Menon DK, Meyfroidt G, Mirasol MAL, Misset B, Molton JS, Mondragon AV, Monsalve DM, Moradi Choghakabodi P, Morpeth SC, Mouncey PR, Moutschen M, Müller-Tidow C, Murphy E, Najdovski T, Nichol AD, Nielsen H, Novak RM, O'Sullivan MVN, Olalla J, Osibogun A, Osikomaiya B, Oyonarte S, Pardo-Oviedo JM, Patel MC, Paterson DL, Peña-Perez CA, Perez-Calatayud AA, Pérez-Alba E, Perkina A, Perry N, Pouladzadeh M, Poyato I, Price DJ, Quero AKH, Rahman MM, Rahman MS, Ramesh M, Ramírez-Santana C, Rasmussen M, Rees MA, Rego E, Roberts JA, Roberts DJ, Rodríguez Y, Rodríguez-Baño J, Rogers BA, Rojas M, Romero A, Rowan KM, Saccona F, Safdarian M, Santos MCM, Sasadeusz J, Scozzari G, Shankar-Hari M, Sharma G, Snelling T, Soto A, Tagayuna PY, Tang A, Tatem G, Teofili L, Tong SYC, Turgeon AF, Veloso JD, Venkatesh B, Ventura-Enriquez Y, Webb SA, Wiese L, Wikén C, Wood EM, Yusubalieva GM, Zacharowski K, Zarychanski R, Khanna N, Moher D, Goodman SN, Ioannidis JPA, Hemkens LG. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials. BMC Infect Dis. 2021 Nov 20;21(1):1170. doi: 10.1186/s12879-021-06829-7. PMID: 34800996; PMCID: PMC8605464.

Wierda WG, Allan JN, Siddiqi T, Kipps TJ, Opat S, Tedeschi A, Badoux XC, Kuss BJ, Jackson S, Moreno C, Jacobs R, Pagel JM, Flinn I, Pak Y, Zhou C, Szafer-Glusman E, Ninomoto J, Dean JP, James DF, Ghia P, Tam CS. Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study. J Clin Oncol. 2021 Dec 1;39(34):3853-3865. doi: 10.1200/JCO.21.00807. Epub 2021 Oct 7. PMID: 34618601; PMCID: PMC8713593.

Aliberti S, Goeminne PC, O'Donnell AE, Aksamit TR, Al-Jahdali H, Barker AF, Blasi F, Boersma WG, Crichton ML, De Soyza A, Dimakou KE, Elborn SJ, Feldman C, Tiddens H, Haworth CS, Hill AT, Loebinger MR, Martinez-Garcia MA, Meerburg JJ, Menendez R, Morgan LC, Murris MS, Polverino E, Ringshausen FC, Shteinberg M, Sverzellati N, Tino G, Torres A, Vandendriessche T, Vendrell M, Welte T, Wilson R, Wong CA, Chalmers JD. Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations. Lancet Respir Med. 2021 Sep 24:S2213-2600(21)00277-0. doi: 10.1016/S2213-2600(21)00277-0. Epub ahead of print. PMID: 34570994.

Gane E, Yuen MF, Kim DJ, Chan HL, Surujbally B, Pavlovic V, Das S, Triyatni M, Kazma R, Grippo JF, Buatois S, Lemenuel-Diot A, Krippendorff BF, Mueller H, Zhang Y, Kim HJ, Leerapun A, Lim TH, Lim YS, Tanwandee T, Kim W, Cheng W, Hu TH, Wat C. Clinical Study of Single-Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B. Hepatology. 2021 Oct;74(4):1795-1808. doi: 10.1002/hep.31920. Epub 2021 Aug 25. PMID: 34037271.

Middlemore Clinical Trials is now on Twitter!
Follow us to stay updated on clinical research news that is conducted right here at Middlemore Hospital.

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Meet the Team - Sharon Cheung (Business Associate)

Sharon has a Master of Science degree, majoring in physiology. She has a background in academic research with interests in fetal physiology and preeclampsia. She is looking forward to gaining industry experience and working with CMH investigators to bring exciting trials to Middlemore.

Sharon's role at MMCT is highly varied, she assists Kate Msiska (Business Manager) with budget and contract negotiations for new clinical trials and she manages the social media marketing for the unit. She is also involved in developing recruitment plans for trials.

Trials starting at MMCT

List of upcoming trials that are planned to start recruiting in the next three months:

To learn more about the trials we are performing at Middlemore Hospital, please visit our website and see what trials in what disease areas we are currently working on.

Together through research we can improve the lives of many of the patients in Counties Manukau.

View Current Recruiting Trials

NEW: Clinical Trial Referral App available to download. Stay up to date for clinical trials recruiting at Middlemore Hospital

Scan the QR Code to Download the ClinTrial Refer App

MMCT Contacts

Type of Enquiry	Person	Email Address
Feasibilities	Kate Msiska	feasibility@mmclintrials.nz
Trial Contracts	Kate Msiska	contracts@mmclintrials.nz
Finance	Emani Setefano	finance@mmclintrials.nz
Investigator Initiated (Grant Funded) Trials	Dr Nicola Jackson	grants @mmclintrials.nz
Regulatory/Ethics	Catherine Howie	ethics@mmclintrials.nz
For support when a clinically significant event occurs with a trial	Dr John Baker	John.Baker@mmclintrials.nz
To refer a patient for a clinical trial	Please visit our website or use the ClinTrial Refer App	Recruiting Trials Page Emma.Dorsey@mmclintrials.nz